Supercomputers based on Xeon processors that have been in the top ten of the Top500 fastest supercomputers in the world are:

• After upgrades from Pentium Pro to Xeon, ASCI Red reclaimed its #1 spot in 1999 with a speed of 2.4 TFLOPS.^[23]
• an Intel Xeon system at SGI in Chippewa Falls, Wisconsin. Machine: SGI Altix ICE 8200 system with 3584 Quad-Core Clovertown processors at 3.0 GHz and InfiniBand interconnect. This supercomputer was listed in third place in November 2007, ahead of the fastest Itanium and Opteron-based supercomputers but behind two PowerPC-based Blue Gene systems.^[24]

Xeon processor based system, in the top 20 of the fastest systems by memory bandwidth as measured by STREAM benchmark:^[25]

• an Intel Xeon virtual SMP system leveraging ScaleMP's Versatile SMP (vSMP) architecture with 128 cores and 1TB RAM.^[26] This system aggregates 16 Stoakley platform (Seaburg chipset) systems with total of 32 Harpertown processors.